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Centre for Inflammation Research and Translational Medicine (CIRTM)

The Centre was established to promote interdisciplinary research into understanding the inflammatory and immune processes that underlie human health, disease and healing.

Contact us

For general enquiries please contact our Centre Administrator, Mrs. Coral Hankins. For scientific enquiries please e-mail the Centre Director: Professor Felicity N. E. Gavins directly. 

Take part in our research seminars and online events

Currently, all seminars are being delivered online via Teams. See more here.

Where is CIRTM?

We are located on the Brunel University London campus in Uxbridge.  Find travelling directions here.

Research within CIRTM

Research forms the core of the CIRTM, around which all our other activities (e.g. training, teaching, clinical care and outreach) occur. 

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Cardiovascular Diseases

Cardiovascular diseases and its risk factors include diseases and conditions such as type2 diabetes, hypertension, heart attack, heart failure, and stroke. 

The various research performed at CIRTM include population-based research and lab-based science. Our population-based research is aimed to identify determinants and predicting factors of cardiovascular diseases at population level by investigating data from large number of individuals. Our lab-based approaches tries to find novel therapeutic factors at cellular and molecular level using animal and cellular models. For instance, we investigate effect of various therapeutic compounds in immune response in heart muscle after heart attack.

Cancers

Cancers are one of the most important causes or disability and early death in developed countries. At CIRTM, we work on cellular and molecular factors that improves immunity against cancers.  We additionally investigate mice models to understand genetic modifications that induce cancers . We investigate adult-onset cancers as well as childhood cancers such as neuroblastoma and leukaemia to understand molecular and genetic interactions in occurrence of the disease.

Infections

Infections are still considered as important public health burden globally. At CIRTM, we investigate the role of immune system and antimicrobial compounds on various infectious diseases such as tuberculosis and burn injury infections. We also investigate dynamics of the gut microbiome as a results of diseases or injuries.

Tuberculosis is a chronic infection that can affect many organs in the body including lungs. At CIRTM, we work on immunologic aspects of Tuberculosis to understand how the host immune system works at the time of infection. We additionally work on innovative ways to improve vaccine-induced immune response and effectiveness of tuberculosis vaccine (BCG).

Microbial Resistance

The discovery of penicillin over 90 years ago and its subsequent uptake by healthcare systems around the world revolutionised global health and wellbeing. It marked the beginning of a golden age in antibiotic discovery with new classes of antibiotics being routinely discovered and saving millions of lives annually. However, towards the end of the last century the rate of discovery slowed to a near standstill. This lack of discovery has been compounded by the rapid emergence and spread of bacterial pathogens that exhibit resistance to multiple antibiotic treatments threatening the sustainability of healthcare systems globally. In fact, it is estimated that by 2050, antibiotic resistance may be responsible for up to 50 million deaths per year. In the CIRTM, we aim to understand how bacteria evolve resistance to specific antibiotics and to characterise the different mechanisms enabling this resistance. We have a particular focus on understanding biofilm formation, a community like behaviour that allows bacteria to overcome exposure to antibiotics. We have also established a robust drug discovery pipeline that aims to identify and profile novel compounds that can disrupt the virulence mechanisms that bacteria use to establish infection or overcome antibiotic therapy. 

Browse our research projects

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Our funding partners

We have great success at securing grant funding for our research and our partners include some of the biggest names in the area. 

Watch our research videos

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Reducing inflammation in the brain after stroke

Professor Felicity Gavins explains her stroke research in The Royal Society video

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Understanding adenoid cystic carcinoma

Professor Arturo Sala explains his research with the Oracle Cancer Trust

Postgraduate research opportunities

Specialist facilities and equipment 

The CIRTM resides within the Division of Biosciences at Brunel University London, with members taking full advantage of recent research infrastructure investments to support cutting edge research.