Adenoid cystic carcinoma is characterised by slow but relentless growth that is only minimally affected by therapeutic treatments. Despite radio- and chemo-therapy, metastatic adenoid cystic carcinomas invariably progress until the patient succumb to the disease. In this research, we will investigate the role of the transcription factor and protooncogene MYB, frequently altered in adenoid cystic carcinoma, in promoting radio and chemo-resistance.
The central hypothesis that will be investigated is whether MYB gene rearrangements/overexpression in adenoid cystic carcinoma lead to activation of ATR, ATM, BUB1 and resistance to radiation and/or DNA damaging agents. A further aim will be to investigate whether disruption of the MYB > (ATR, ATM, BUB1) axis could cause enhanced sensitivity of cancer cells to radiation and/or chemotherapy, with the ultimate objective of improving treatment and survival of cancer patients.
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Inflammation Research and Translational Medicine - Driving scientific innovation and discovery for diagnosis, treatment, and management of cardiovascular disease, inflammatory and immune disorders, microbial resistance, and cancer.
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Project last modified 18/06/2021